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Sasaki, Yuji; Kaneko, Masashi; Ban, Yasutoshi; Matsumiya, Masahiko*; Nakase, Masahiko*; Takeshita, Kenji*
Separation Science and Technology, 57(16), p.2543 - 2553, 2022/00
Times Cited Count：3 Percentile：29.84(Chemistry, Multidisciplinary)The mutual separation of actinides (An) from lanthanides (Ln) using the masking agent of DTPA (diethylenetriamine-pentaacetic acid) or DTBA (diethylenetriamine-triacetic acid-bis(diethylacetamide)) in the aqueous phase through DGA extraction, referring TALSPEAK method, is focused. We investigate to obtain the same separation performance using commercially available DTPA on that using DTBA. In this work, we select lactic acid (LA) of pH buffer from 10 organic acids and ethylenediamine (ED) for the pH adjustment. Almost the same D and SF values are obtained among the conditions: TODGA-DTPA-LA-NaOH, TODGA-DTPA-LA-ED, and TODGA-DTBA-LA. The experimental results using batchwise multi-stage extractions show the average yields of Ln (La to Gd) and Am to be 3.73 and 98.1% in the aqueous phase using DGA-DTPA-LA-ED, to be 3.1 and 97.0% using DGA-DTPA-LA-NaOH, and to be 1.61 and 98.7% using DGA-DTBA-LA.
systemSasaki, Yuji; Morita, Keisuke; Matsumiya, Masahiko*; Nakase, Masahiko*
Radiochimica Acta, 108(9), p.689 - 699, 2020/09
Times Cited Count：9 Percentile：75.92(Chemistry, Inorganic & Nuclear)The simultaneous separation of Am and Cm from lanthanides is important for atomic energy fields. All lanthanides, Am, and Cm can be extracted by diglycolamide (DGA). In addition, relatively high separation factors between An and Ln were obtained by the extraction system of TODGA, DTPA (diethylenetriamine-pentaacetic acid) and HNO. In this work, DTPA-BA (diethylenetriamine-triacetic-bisamide), which is an improved version of DTPA, was employed for the separation of Ln and An. A relatively high separation factor (approximately 8) for actinides/lanthanides was obtained. Then, the multi-step extraction was performed. Thus, the recoveries of 94.7% for Nd and 4.7% for Am and Cm in organic phase, and 5.3% Nd and 95.3% for Am and Cm in aqueous phase were obtained.
Sasaki, Yuji; Morita, Keisuke
Progress in Nuclear Science and Technology (Internet), 5, p.27 - 32, 2018/12
no abstracts in English
-dodecaneApichaibukol, A.; Sasaki, Yuji; Morita, Yasuji
Solvent Extraction and Ion Exchange, 22(6), p.997 - 1011, 2004/12
Times Cited Count：41 Percentile：71.45(Chemistry, Multidisciplinary)no abstracts in English
evaluation of BPA-Gd-DTPA complex as an MRI contrast agent and as a carrier for neutron capture therapyTakahashi, Kazunori*; Nakamura, Hiroyuki*; Furumoto, Shozo*; Yamamoto, Kazuyoshi; Matsumura, Akira*; Fukuda, Hiroshi*; Yamamoto, Yoshinori*
Proceedings of 11th World Congress on Neutron Capture Therapy (ISNCT-11) (CD-ROM), 1 Pages, 2004/10
We synthesized a BPA-Gd-DTPA compound, as a carrier for neutron capture therapy to be used for MRI contrast media. Pinanediol was used as the protective group for B(OH)2 group of BPA, and the BPA unit was connected to the DTPA framework through an amide bond. The biodistribution studies were performed after injection of the compound into AH109A hepatoma bearing Donryu rats. The concentrations of Gd and boron were measured by prompt g-ray analyses. The tumor uptakes (% ID/g) were 1% and 0.3% at 20 min and 60 min after injection, respectively and were higher than that of carborane-Gd-DTPA, which we previously reported. However, liver and kidney uptake was very high and tumor/blood ratio was very low (0.38) compared to that of BPA itself (ca. 3.0). Alfa autoradiogram of a tumor bearing rat showed higher concentration of boron in the tumor compared to surrounding muscle and very high in the intestine. Although tumor selectivity of the compound was higher than that of carborane-Gd-DTPA, further studies of the synthesis and in vivo evaluation of better binary compounds are continuing.
Yamagishi, Isao; Yamaguchi, Isoo; Kubota, Masumitsu*
JAERI-Research 2000-038, 40 Pages, 2000/09
JAERI-Research-2000-038.pdf:1.33MB
no abstracts in English
Kobayashi, Katsutoshi; *
Isotope News, p.12 - 14, 1998/02
no abstracts in English
JAERI 1288, 30 Pages, 1983/10
no abstracts in English
;
Journal of Nuclear Science and Technology, 19(4), p.326 - 333, 1982/00
Times Cited Count：22 Percentile：87.44(Nuclear Science & Technology)no abstracts in English
Ce from a contaminated wound in the rat;
Health Physics, 37(3), p.401 - 405, 1979/00
no abstracts in English
; ;
Journal of Nuclear Science and Technology, 16(6), p.434 - 440, 1979/00
Times Cited Count：16no abstracts in English
;
Journal of Radioanalytical Chemistry, 52(2), p.343 - 354, 1979/00
no abstracts in English
Ce in the ratStrahlentherapie, 153(3), p.195 - 199, 1977/03
no abstracts in English
Takada, Kazuo
Hoken Butsuri, 12(1), p.19 - 24, 1977/01
no abstracts in English
Ce administered subcutaneously, intramuscularly and intravenously in rats;
Journal of Radiation Research, 14(2), p.187 - 197, 1973/02
no abstracts in English
Ce accompanied with different levels of carrierHealth Physics, 23(4), p.481 - 489, 1972/04
Times Cited Count：4no abstracts in English
Sasaki, Yuji; Kaneko, Masashi; Matsumiya, Masahiko*; Nakase, Masahiko*; Takeshita, Kenji*
no journal, ,
The history of development of DGA compounds in our laboratory and their extraction ability will be mentioned. In addition, it is effective to separate An from Ln by back-extraction after lumping together extractions of An + Ln, and we can use various aqueous phase in the back-extraction. In this case we use organic acid, thus the results of separation of An and Ln using DTPA-BA dissolved in organic acid will be discussed.
Sasaki, Yuji; Kaneko, Masashi; Ban, Yasutoshi
no journal, ,
A selective back-extraction method using DTPA and DTBA as complexants has been developed for mutual separation of actinides and lanthanides (Ln) extracted by TODGA. A novel complexant of DTBA (diethlenetriamine-triaceticdiamide) had high solubility in water and strongly coordinated to Am under lower pH condition than that of DTPA. Multi-stage extraction experiments using DTPA and DTBA showed that the back-extraction ratios of Am and Ln were over 97% and under 3%, respectively. The effects of organic amines, such as ethlenediamine, on the complexation of Am and pH adjustment in the aqueous phase will also be presented.
Sasaki, Yuji; Kaneko, Masashi; Ban, Yasutoshi; Matsumiya, Masahiko*; Nakase, Masahiko*; Takeshita, Kenji*
no journal, ,
In our group, the separation of An from Ln is performed using batch-wise multi stage extraction. The condition, DGA(diglycolamide)-DTPA(diethylenetriamine-pentaacetic acid) or DGA-DTBA(diethylenetriamine-triacetic diamide),showed approximate 10 of D(Am)/D(Ln). The multi stage extraction of 10 
10 of organic and aqueous phase numbers gives successfully 97% of Am with 3% of Ln in the aqueous phase.
